The association between regional transcriptome profiles and lung volumes in response to mechanical ventilation and lung injury.
Yong SongSeiha YenMelissa PreissnerEllen BennettStephen DubskyAndreas FourasPeter A DargavilleGraeme R ZoskyPublished in: Respiratory research (2022)
The biological pathways associated with lung volume inhomogeneity during MV, and MV in the presence of pre-existing inflammation, differed. MV related tidal stretch induced up-regulation of immune response genes, while LPS combined with MV disrupted PI3K/Akt and MEK/ERK signalling.
Keyphrases
- pi k akt
- mechanical ventilation
- signaling pathway
- cell proliferation
- immune response
- cell cycle arrest
- acute respiratory distress syndrome
- intensive care unit
- genome wide
- oxidative stress
- inflammatory response
- high glucose
- single cell
- rna seq
- diabetic rats
- gene expression
- respiratory failure
- toll like receptor
- anti inflammatory
- dendritic cells
- carbon dioxide
- dna methylation