Serum total bilirubin level is associated with contrast induced nephropathy after primary percutaneous coronary intervention.
Murat Oğuz ÖzilhanSadık Kadri AçıkgözPublished in: Angiology (2023)
Contrast Induced Nephropathy (CIN) is a major complication of angiographic procedures. Primary percutaneous coronary intervention (pPCI) is the preferred treatment for ST-segment elevation myocardial infarction (STEMI) but is associated with a risk of CIN. Oxidative stress and free radical damage play a role in the pathogenesis of CIN. Bilirubin has anti-inflammatory and antioxidant activity and has been shown to have a protective effect on endothelial cells. The present study aimed to assess the association between serum bilirubin level and development of CIN after pPCI. Sequential STEMI patients (n = 595) who underwent pPCI between January 2021 and December 2022 were enrolled. Among the participants, 116 (19.5%) developed CIN. Serum total bilirubin level was significantly lower in the CIN group ( P = .001). In multivariate logistic regression analysis, serum bilirubin level was found as an independent predictor of CIN. Age, gender, contrast volume, and white blood cell count were other independent predictors of CIN. A higher serum bilirubin level is associated with a lower risk of CIN in the present study. In STEMI patients undergoing pPCI, serum bilirubin level may be helpful to predict the risk of CIN and may help ensure early initiation of preventive treatment and careful follow-up.
Keyphrases
- percutaneous coronary intervention
- st segment elevation myocardial infarction
- st elevation myocardial infarction
- acute coronary syndrome
- acute myocardial infarction
- oxidative stress
- coronary artery disease
- antiplatelet therapy
- endothelial cells
- coronary artery bypass grafting
- patients undergoing
- high glucose
- end stage renal disease
- chronic kidney disease
- dna damage
- atrial fibrillation
- stem cells
- coronary artery bypass
- ejection fraction
- diabetic rats
- newly diagnosed
- magnetic resonance imaging
- contrast enhanced
- cell therapy
- signaling pathway
- single cell
- induced apoptosis
- peripheral blood
- heat shock protein