Reference Curves for Pediatric Endocrinology: Leveraging Biomarker Z-Scores for Clinical Classifications.
Andre Greger MadsenBjørg AlmåsIngvild Særvold BruserudNinnie Helen Bakken OehmeChristopher Sivert NielsenMathieu RoelantsThomas HundhausenMarie Lindhardt LjubicicRobert BjerknesGunnar MellgrenJørn V SagenPétur B JuliussonKristin VistePublished in: The Journal of clinical endocrinology and metabolism (2022)
Biomarker reference curves and corresponding z-scores provide an intuitive framework for clinical implementation in pediatric endocrinology and facilitate the application of machine learning classification and covariate precision medicine for pediatric patients.