Monitoring the Progression of Chronic Liver Damage in Rats Using [18F]PBR06.

[18F]PBR06 can serve as a sensitive probe to monitor the progression of inflammation in liver. [18F]PBR06 imaging may be used to accurately assess liver damage degree and guide the therapeutic schedule, especially for those patients with severe liver inflammation and damage but with normal or mildly elevated serum ALT and AST. As a non-invasive diagnostic application, [18F]PBR06 PET scan could be an alternative for patients who is unwilling to perform liver biopsy.