YAP inhibition overcomes adaptive resistance in HER2-positive gastric cancer treated with trastuzumab via the AKT/mTOR and ERK/mTOR axis.

Jiao QiaoMei FengWenyuan ZhouYuan TanShuo YangQi LiuQingchen WangWeimin FengYisheng PanLiyan Cui

Published in: Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association (2024)

These findings underscore the pivotal role of reactivated YAP and mTOR signaling pathways in the development of adaptive resistance to trastuzumab and may serve as a promising joint target to overcome resistance to trastuzumab.

Keyphrases

cell proliferation
signaling pathway
epidermal growth factor receptor
metastatic breast cancer
pi k akt
epithelial mesenchymal transition
induced apoptosis