Overproduced bone marrow neutrophils in collagen-induced arthritis are primed for NETosis: An ignored pathological cell involving inflammatory arthritis.
Danyi XuYiming LinJinming ShenJie ZhangJinghua WangYuwei ZhangHong ZhangLonggui NingPeihao LiuSha LiHang ZengJin LinChaohui YuPublished in: Cell proliferation (2020)
We propose for the first time that the overproduced BM neutrophils in CIA mice are primed for NETosis in a G-CSF dependent manner, and these pathogenic cells may have an important role in inflammatory arthritis. Blocking this pathological process could be a potential strategy for the treatment of RA.
Keyphrases
- rheumatoid arthritis
- bone marrow
- induced apoptosis
- oxidative stress
- disease activity
- mesenchymal stem cells
- single cell
- cell cycle arrest
- diabetic rats
- high glucose
- cell therapy
- endoplasmic reticulum stress
- high fat diet induced
- type diabetes
- signaling pathway
- endothelial cells
- systemic lupus erythematosus
- climate change
- cell proliferation
- tissue engineering
- wild type
- stress induced