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A povarov-type reaction to access tetrahydroquinolines from N -benzylhydroxylamines and alkenes in HFIP.

Valentyn PozhydaievDaniella Al-OthmanJoseph MoranDavid Lebœuf
Published in: Chemical communications (Cambridge, England) (2024)
Here, we report the synthesis of tetrahydroquinolines between newly developed N -benzylhydroxylamine reagents and alkenes using HFIP as a solvent. This transformation is notably applicable to highly electronically deactivated styrenes and aliphatic alkenes, expanding the range of tetrahydroquinolines attainable.
Keyphrases
  • electron transfer