Characterization of Skeletal Phenotype and Associated Mechanisms With Chronic Intestinal Inflammation in the Winnie Mouse Model of Spontaneous Chronic Colitis.
Ahmed Al SaediShilpa SharmaEbrahim Bani HassanLulu ChenAli Ghasem-ZadehMajid HassanzadeganroudsariJonathan H GooiRhian StavelyRajaraman EriDengshun MiaoKulmira NurgaliGustavo DuquePublished in: Inflammatory bowel diseases (2021)
Skeletal phenotype of the Winnie mouse model of spontaneous chronic colitis closely represents manifestations of IBD-associated osteoporosis/osteopenia. The onset and progression of intestinal inflammation are associated with increased gut-derived serotonin level, increased bone resorption, and decreased bone formation.