Nucleotide depletion in hypoxia experimental models of mouse myocardial slices.

Magdalena A Zabielska-KaczorowskaKlaudia StawarskaAda KaweckaKrzysztof UrbanowiczRyszard T SmolenskiBarbara Kutryb-Zajac

Published in: Nucleosides, nucleotides & nucleic acids (2024)

A short-term culture of myocardial slices in a hypoxic chamber seems to be an appropriate model of cardiac ischemia for testing new pharmacological approaches based on modulating the energy metabolism of cardiac cells.

Keyphrases

left ventricular
induced apoptosis
cell cycle arrest
signaling pathway
heart failure
oxidative stress