Osteoblasts impair cholesterol synthesis in chondrocytes via Notch1 signalling.

Yueyi YangDemao ZhangDaimo GuoJiachi LiSiqun XuJieya WeiJing XieXuedong Zhou

Published in: Cell proliferation (2021)

For the first time, we elucidated that communication with osteoblasts reduces cholesterol synthesis in chondrocytes through Notch1 signalling. This result may provide a better understanding of the effect of subchondral bone signalling on chondrocytes.

Keyphrases

extracellular matrix
low density lipoprotein
cell proliferation