Monocytes enhance neutrophil-induced blister formation in an ex vivo model of bullous pemphigoid.

E de GraauwC SitaruM P HornL BorradoriS YousefiDagmar Simon Hans-Uwe Simon

Published in: Allergy (2018)

Our observations suggest that the interaction of cells, as shown here for monocytes and neutrophils, enhances mediator release resulting in an increased subepidermal blister formation. Thus, blocking intercellular cross talk promises a new therapeutic approach for blocking tissue damage in BP.

Keyphrases

induced apoptosis
dendritic cells
peripheral blood
oxidative stress
cell cycle arrest
high glucose
diabetic rats
endoplasmic reticulum stress
signaling pathway
cell proliferation
endothelial cells
stress induced