Effect of roasted peanut allergen Ara h 3 protein on the sensitization of Caco-2 cells.

Shuo WangXiaodong SunMinjia WangZhirui DengBing NiuQin Chen

Published in: Journal of the science of food and agriculture (2021)

These finding identify the mechanisms of the allergenicity of roasted peanut allergy proteins are probably associated with intestinal uptake and cytokine dependent allergies. The aggravated allergic reaction might be caused by the increment of TSLP, IL-6, IL-8 and MCP-1 due to the activated NF-κB signaling pathway, and the enhanced transport of Ara h 3-roasted protein by Caco-2 monolayer. © 2021 Society of Chemical Industry.

Keyphrases

signaling pathway
induced apoptosis
pi k akt
cell cycle arrest
protein protein
epithelial mesenchymal transition
amino acid
endoplasmic reticulum stress
allergic rhinitis
lps induced
small molecule
cell death
nuclear factor
toll like receptor
transition metal