A comparative analysis of IDH-mutant glioma in pediatric, young adult, and older adult patients.

Mary Jane Lim-FatJennifer A Cotter Mehdi TouatJayne VogelzangCecilia SousaWill PisanoJack GeduldigVarun BhaveJoseph DriverPei-Chi KaoAlana McGovernClement MaAshley S MargolKristina ColeAmy SmithStewart GoldmanKristiyana KanevaAi Lien TruongKellie J NazemiMatthew D WoodKaren D WrightWendy B LondonKatherine E WarrenPatrick Y WenWenya Linda BiSanda AlexandrescuDavid A ReardonKeith L LigonKee Kiat Yeo

Published in: Neuro-oncology (2024)

IDH-mutant glioma YA patients had significantly shorter PFS and time to MT but did not differ in OS compared to pediatric and adult groups. Treatment approach varied significantly by patient age and warrant further study as addressable age-associated outcome drivers.

Keyphrases

wild type
end stage renal disease
young adults
newly diagnosed
childhood cancer
low grade
chronic kidney disease
physical activity
peritoneal dialysis
prognostic factors
community dwelling
replacement therapy
smoking cessation