Cutaneous herald: leukaemia cutis as presenting manifestation of relapse in acute promyelocytic leukaemia.
Prasanth BalasubramanianRam Vasudevan NampoothiriDeepak GoniPankaj MalhotraPublished in: BMJ case reports (2018)
Leukaemia cutis or cutaneous infiltration of neoplastic myeloid or lymphoid cells is usually seen in the acute myelomonocytic and acute monocytic variants of acute myeloid leukaemia. Here, we report a case of acute promyelocytic leukaemia who achieved remission, presenting with skin lesions, the biopsy of which revealed leukaemia cutis, heralding the relapse of the disease. After establishing the diagnosis with bone marrow analysis, the patient was started on daunorubicin chemotherapy along with arsenic trioxide and all-trans retinoic acid. Afterwards, the skin lesions resolved, and the patient is planned for consolidation with bone marrow transplantation.
Keyphrases
- liver failure
- bone marrow
- respiratory failure
- case report
- aortic dissection
- drug induced
- mesenchymal stem cells
- hepatitis b virus
- acute myeloid leukemia
- induced apoptosis
- squamous cell carcinoma
- gene expression
- risk assessment
- intensive care unit
- oxidative stress
- heavy metals
- cell proliferation
- rectal cancer
- endoplasmic reticulum stress
- locally advanced
- cell cycle arrest
- ulcerative colitis