Silica nanoparticles inhibit the cation channel TRPV4 in airway epithelial cells.
Alicia SanchezJulio L AlvarezKateryna DemydenkoCarole JungYeranddy A AlpizarJulio Alvarez-CollazoStevan M CokicMiguel A ValverdePeter H HoetKarel TalaveraPublished in: Particle and fibre toxicology (2017)
Our results show that SiNPs inhibit TRPV4 activation, and that this effect may impair the positive modulatory action of the stimulation of this channel on the ciliary function in airway epithelial cells. These findings unveil the cation channel TRPV4 as a primary molecular target of SiNPs.