Hemorrhagic risk after intravenous thrombolysis for ischemic stroke in patients with cerebral microbleeds and white matter disease.

Maria Luisa CapuanaSvetlana LorenzanoMaria Chiara CaselliMaurizio PaciaroniDanilo Toni

Published in: Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology (2020)

The results of our study suggest that the exclusion of eligible candidates to administration of IV rt-PA only on the basis of CMBs presence is not justified. The clinical decision should be weighed with a case-by-case approach. Additional data are needed to evaluate the benefit-risk profile of rt-PA in patients carrying numerous microbleeds.

Keyphrases

white matter
end stage renal disease
newly diagnosed
chronic kidney disease
ejection fraction
pulmonary embolism
prognostic factors
electronic health record
big data
acute ischemic stroke
machine learning
low dose
patient reported outcomes
decision making
blood brain barrier
patient reported
breast cancer risk