Exploring Metabolic Consequences of CPS1 and CAD Dysregulation in Hepatocellular Carcinoma by Network Reconstruction.

Ozbil E DumenciMei Ran Abellona U Shahid A KhanElaine HolmesSimon D Taylor-Robinson

Published in: Journal of hepatocellular carcinoma (2020)

Information from different databases was collated to form an informative network that integrated different "-omics" approaches, demonstrating the relationships between genetic and metabolic components of urea cycle and the de novo pyrimidine biosynthesis pathway. This study paves the way for further research by acting as a template to investigate the relationships between genes and metabolites, explore their potential roles in various diseases and aid the development of new screening and treatment methods through network reconstruction.

Keyphrases

genome wide
ms ms
copy number
gene expression
big data
social media
mass spectrometry
molecularly imprinted