A unique cytotoxic CD4 + T cell-signature defines critical COVID-19.
Sarah BairdCaroline L AshleyFelix Marsh-WakefieldSibel AlcaThomas Myles AshhurstAngela L FergusonHannah LukemanClaudio CounoupasJeffrey J PostPamela KonecnyAdam BartlettMarianne MartinelloRowena A BullAndrew LloydAlice GreyOwen HutchingsUmaimainthan PalendiraWarwick J BrittonMegan SteainJames A TriccasPublished in: Clinical & translational immunology (2023)
T-cell responses may contribute to cell-mediated host tissue damage and progression of COVID-19. Induction of these potentially detrimental T-cell responses should be considered when developing and implementing effective COVID-19 control strategies.