Lactamization of sp(2) C-H Bonds with CO2 : Transition-Metal-Free and Redox-Neutral.
Zhen ZhangLi-Li LiaoSi-Shun YanLei WangYun-Qi HeJian-Heng YeJing LiYong-Gang ZhiDa-Gang YuPublished in: Angewandte Chemie (International ed. in English) (2016)
The first direct use of carbon dioxide in the lactamization of alkenyl and heteroaryl C-H bonds to synthesize important 2-quinolinones and polyheterocycles in moderate to excellent yields is reported. Carbon dioxide, a nontoxic, inexpensive, and readily available greenhouse gas, acts as an ideal carbonyl source. Importantly, this transition-metal-free and redox-neutral process is eco-friendly and desirable for the pharmaceutical industry. Moreover, these reactions feature a broad substrate scope, good functional group tolerance, facile scalability, and easy product derivatization.
Keyphrases
- carbon dioxide
- ms ms
- machine learning
- liquid chromatography tandem mass spectrometry
- high intensity
- high performance liquid chromatography
- gas chromatography mass spectrometry
- quantum dots
- electron transfer
- liquid chromatography
- tandem mass spectrometry
- highly efficient
- transition metal
- amino acid
- ultra high performance liquid chromatography
- high resolution mass spectrometry