Domino Reaction between Nitrosoarenes and Ynenones for Catalyst-Free Preparation of Indanone-Fused Tetrahydroisoxazoles.

A catalyst-free domino reaction to synthesize highly functionalized indanone-fused tetrahydroisoxazole from easily accessed nitrosoarene and 1,6-ynenone with good chemo- and regioselectivity was disclosed. This unprecedented domino reaction represents a new strategy for multifunctionalization of an internal alkyne with nitrosoarene by formation of two rings and four bonds in a single operation.