Genomic epidemiology and longitudinal sampling of ward wastewater environments and patients reveals complexity of the transmission dynamics of bla KPC -carbapenemase-producing Enterobacterales in a hospital setting.
Nicole E StoesserR GeorgeZ AikenH T T PhanS LipworthT P QuanA J MathersN De MaioA C SealeD W EyreA VaughanJ SwannT E A PetoD W CrookJ CawthorneA DodgsonA S Walkernull nullPublished in: JAC-antimicrobial resistance (2024)
We identified substantial and diverse KPC-E colonization of wastewater sites and patients in this hospital setting. Reservoir and niche-specific factors (e.g. microbial interactions, selection pressures), and different strains and mobile genetic elements likely affect transmission dynamics. This should be considered in surveillance and control strategies.
Keyphrases
- end stage renal disease
- klebsiella pneumoniae
- ejection fraction
- newly diagnosed
- chronic kidney disease
- healthcare
- public health
- peritoneal dialysis
- emergency department
- gene expression
- wastewater treatment
- dna methylation
- copy number
- adverse drug
- genome wide
- acute care
- anaerobic digestion
- electronic health record
- patient reported