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Macrophage-derived multinucleated giant cells: hallmarks of the aging ovary.

K Grace FoleyMichele T PritchardFrancesca E Duncan
Published in: Reproduction (Cambridge, England) (2022)
Inflammaging is a state of chronic, low-grade inflammation associated with aging which contributes to age-related diseases. Recently, an age-associated increase in inflammation has been documented in the mammalian ovary, which is accompanied by a shift in the immune cell profile. In this Point of View article, we consider a unique population of macrophage-derived multinucleated giant cells, found in reproductively old mouse ovaries, as potential markers or functional drivers of inflammation in ovarian aging.
Keyphrases
  • low grade
  • induced apoptosis
  • oxidative stress
  • cell cycle arrest
  • high grade
  • endoplasmic reticulum stress
  • cell death
  • cell proliferation
  • pi k akt
  • climate change