S-nitrosoglutathione inhibits cerebrovascular angiotensin II-dependent and -independent AT1 receptor responses: A possible role of S-nitrosation.

Marie-Lynda BouressamSandra LecatAlexandre RaoulCaroline GaucherCaroline Perrin-SarradoIsabelle LartaudFrançois Dupuis

Published in: British journal of pharmacology (2019)

In rat middle cerebral arteries, GSNO pretreatment specifically affects the AT1 receptor and reduces both AngII-dependent and AngII-independent activation, most likely through AT1 receptor S-nitrosation.

Keyphrases

angiotensin ii
vascular smooth muscle cells
oxidative stress
brain injury