m6A modification-mediated BATF2 acts as a tumor suppressor in gastric cancer through inhibition of ERK signaling.

Jian-Wei XieXiao-Bo HuangQi-Yue ChenYu-Bin MaYa-Jun ZhaoLi-Chao LiuJia-Bin WangJian-Xian LinJun LuLong-Long CaoMi LinRu-Hong TuChao-Hui ZhengChang-Ming HuangPing Li

Published in: Molecular cancer (2020)

Collectively, our findings indicate the pivotal role of BATF2 in GC and highlight the regulatory function of the METTL3/BATF2/p53/ERK axis in modulating GC progression, which provides potential prognostic and therapeutic targets for GC treatment.

Keyphrases

signaling pathway
gas chromatography
pi k akt
cell proliferation
transcription factor
combination therapy
risk assessment
tandem mass spectrometry
replacement therapy
high resolution
liquid chromatography