Th17 cells increase in RRMS as well as in SPMS, whereas various other phenotypes of Th17 increase in RRMS only.

Seema KalraC LowndesL DurantR C StrangeA Al-ArajiClive P HawkinsS John Curnow

Published in: Multiple sclerosis journal - experimental, translational and clinical (2020)

Increased frequencies of Th17 cells are implicated both in RRMS and SPMS. The CCR6 pathway includes Th17, Th22 and Th1 nonclassical cells, of which Th22 and Th1 cells represent the greatest subsets in MS.

Keyphrases

induced apoptosis
cell cycle arrest
endoplasmic reticulum stress
cell death
dendritic cells
regulatory t cells