Sedative Plasma Concentrations and Delirium Risk in Critical Illness.

Joanna L StollingsJennifer L ThompsonBenjamin A FerrellMika ScheininGrant R WilkinsonChristopher G HughesAyumi K ShintaniE Wesley ElyTimothy D GirardPratik P PandharipandeMayur B Patel

Published in: The Annals of pharmacotherapy (2018)

In critically ill patients, higher lorazepam plasma concentrations were associated with delirium, whereas dexmedetomidine plasma concentrations were not. This implies that the reduced delirium risk seen in patients sedated with dexmedetomidine may be a result of avoidance of benzodiazepines, rather than a dose-dependent protective effect of dexmedetomidine.

Keyphrases

cardiac surgery
acute kidney injury
end stage renal disease
hip fracture
newly diagnosed
ejection fraction
peritoneal dialysis
prognostic factors
breast cancer risk