Safety and Pharmacokinetics of Intranasally Administered Heparin.

Hannah M HarrisKatherine L BoyetHao LiuRohini DwivediNicole M AshpoleRitesh TandonGene L BidwellZhi ChengLauren A FasseroChristian S YuVitor H PominDipanwita MitraKerri A HarrisonEric DahlBill J GurleyArun Kumar KothaMahavir Bhupal ChouguleJoshua S Sharp

Published in: Pharmaceutical research (2022)

UFH showed no toxic effects for extended daily intranasal dosing in mice as well as humans. The clearance kinetics of intranasal heparin solution from the nasal cavity indicates potentially protective levels for up to 12 h after dosing.

Keyphrases

venous thromboembolism
growth factor
high fat diet induced
physical activity
type diabetes
metabolic syndrome
adipose tissue
insulin resistance
skeletal muscle