Photobiomodulation Therapy and Pulp-Regenerative Endodontics: A Narrative Review.
Jiawen YongSabine GrögerZuping WuSabine RufYuer YeXiaoyan ChenPublished in: Bioengineering (Basel, Switzerland) (2023)
Regenerative endodontic procedures (REPs) were used to recover the dental pulp's vitality in order to avoid the undesirable outcomes of conventional endodontic treatment and to promote dentinal formation, especially for immature permanent teeth. Photobiomodulation therapy (PBMT) exhibits photobiological and photochemical effects for improving the root canal's environmental conditions by compensating for oxidative stress and increasing the blood supply to implanted stem cells and improving their survival. Basic research has revealed that PBMT can modulate human dental pulp stem cells' (hDPSCs) differentiation, proliferation, and activity, and subsequent tissue activation. However, many unclear points still remain regarding the mechanisms of action induced by PBMT in REPs. Therefore, in this review, we present the applications of laser and PBMT irradiation to the procedures of REPs and in endodontics. In addition, the effects of PBMT on the regenerative processes of hDPSCs are reviewed from biochemical and cytological perspectives on the basis of the available literature. Furthermore, we consider the feasibility of treatment in which PBMT irradiation is applied to stem cells, including dental pulp stem cells, and we discuss research that has reported on its effect.
Keyphrases
- stem cells
- cell therapy
- oxidative stress
- systematic review
- endothelial cells
- dna damage
- mesenchymal stem cells
- radiation therapy
- ischemia reperfusion injury
- type diabetes
- climate change
- signaling pathway
- insulin resistance
- skeletal muscle
- radiation induced
- human health
- replacement therapy
- induced apoptosis
- heat stress
- weight loss