HER2-LAMP vaccines effectively traffic to endolysosomal compartments and generate enhanced polyfunctional T cell responses that induce complete tumor regression.

Alan Chen ChenRenhuan XuTao WangJunping WeiXiao-Yi YangCong-Xiao LiuGangjun LeiHerbert Kim LyerlyTeri HeilandZachary Conrad Hartman

Published in: Journal for immunotherapy of cancer (2021)

These data demonstrate the potential of using LAMP-based endolysosomal trafficking as a means to augment the generation of polyfunctional, antigen-specific T cells in order to improve antitumor therapeutic responses using cancer antigen vaccines.

Keyphrases

loop mediated isothermal amplification
papillary thyroid
squamous cell
electronic health record
big data
risk assessment
data analysis
climate change
quantum dots