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HER2-LAMP vaccines effectively traffic to endolysosomal compartments and generate enhanced polyfunctional T cell responses that induce complete tumor regression.

Alan Chen ChenRenhuan XuTao WangJunping WeiXiao-Yi YangCong-Xiao LiuGangjun LeiHerbert Kim LyerlyTeri HeilandZachary Conrad Hartman
Published in: Journal for immunotherapy of cancer (2021)
These data demonstrate the potential of using LAMP-based endolysosomal trafficking as a means to augment the generation of polyfunctional, antigen-specific T cells in order to improve antitumor therapeutic responses using cancer antigen vaccines.
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