HER2-LAMP vaccines effectively traffic to endolysosomal compartments and generate enhanced polyfunctional T cell responses that induce complete tumor regression.
Alan Chen ChenRenhuan XuTao WangJunping WeiXiao-Yi YangCong-Xiao LiuGangjun LeiHerbert Kim LyerlyTeri HeilandZachary Conrad HartmanPublished in: Journal for immunotherapy of cancer (2021)
These data demonstrate the potential of using LAMP-based endolysosomal trafficking as a means to augment the generation of polyfunctional, antigen-specific T cells in order to improve antitumor therapeutic responses using cancer antigen vaccines.