Essential oil of Schisandra chinensis ameliorates cognitive decline in mice by alleviating inflammation.
Mengjie XuXiaoying ZhangFangyi RenTingxu YanBo WuKaishun BiWenchuan BiYing JiaPublished in: Food & function (2019)
In this study, we aim to assess possible impacts of essential oil (SEO) from Schisandra chinensis (Turcz.) Baill. (S. chinensis) on mice with cognition impairment. Our data showed that SEO improved the cognitive ability of mice with Aβ1-42 or lipopolysaccharides (LPS)-induced Alzheimer's disease (AD) and suppressed the production of tumor necrosis factor-a (TNF-a), interleukin-6 (IL-6), and interleukin-1β (IL-1β) in the hippocampus. Furthermore, SEO inhibited p38 activation, but had little effect on other signaling proteins in the MAPK family, such as extracellular signal-regulated kinase 1/2 (ERK1/2) and c-Jun N-terminal kinase 1/2 (JNK). The SEO and BV-2 microglia co-culture was performed to further confirm the anti-inflammatory activity of SEO. The data showed that SEO decreased nitric oxide (NO) levels in LPS-stimulated BV-2 microglia and significantly blocked LPS-induced MAPKs activation. Taken together, these findings suggested that SEO produces anti-AD effects on AD mice partly by modulating neuroinflammation through the NF-κB/MAPK signaling pathway.
Keyphrases
- lps induced
- inflammatory response
- signaling pathway
- cognitive decline
- essential oil
- pi k akt
- lipopolysaccharide induced
- high fat diet induced
- nitric oxide
- oxidative stress
- mild cognitive impairment
- toll like receptor
- rheumatoid arthritis
- induced apoptosis
- type diabetes
- epithelial mesenchymal transition
- machine learning
- big data
- spinal cord
- deep learning
- cell proliferation
- traumatic brain injury
- neuropathic pain
- metabolic syndrome
- mouse model
- protein kinase
- transcription factor
- data analysis
- multiple sclerosis
- spinal cord injury
- artificial intelligence
- wild type
- blood brain barrier
- white matter