Potentiation of long-acting β2-agonist and glucocorticoid responses in human airway epithelial cells by modulation of intracellular cAMP.

Yechan KimVincent HouRyan D HuffJennifer A AguiarSpencer RevillNicholas TiessenQuynh CaoMatthew S MillerMark D InmanKjetil AskAndrew C DoxeyJeremy Alexander Hirota

Published in: Respiratory research (2021)

Modulation of intracellular cAMP levels by PDE4 or ABCC4 inhibition potentiates LABA/GCS efficacy in human airway epithelial cells challenged with viral stimuli. The data suggest further exploration of the value of adding cAMP modulators to mainstay LABA/GCS therapy in asthma for potentiated anti-inflammatory efficacy.

Keyphrases

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