Comprehensive Transcriptomic Analysis of EWSR1::WT1 Targets Identifies CDK4/6 Inhibitors as an Effective Therapy for Desmoplastic Small Round Cell Tumors.
Justin W MagrathShruthi Sanjitha SampathDane A FlinchumAlifiani Bonita HartonoIlon N GoldbergJulia R BoehlingSuzana D SavkovicSean Bong LeePublished in: Cancer research (2024)
EWSR1::WT1 is essential for desmoplastic small round cell tumors and upregulates the cyclin D-CDK4/6-RB axis that can be targeted with palbociclib, providing a targeted therapeutic strategy for treating this deadly tumor type.