Geospatial Immune Heterogeneity Reflects the Diverse Tumor-Immune Interactions in Intrahepatic Cholangiocarcinoma.

Youpei Lin Lihua Peng Liangqing Dong Dong-Bing Liu Jiaqiang Ma Jian Lin Xiaofang Chen Penghui Lin Qiang Gao Mao Zhang Yuming Liu Junhua Rao Chen Wei Ye Lu Shu Zhang Guangyu Ding Zhenyu Peng Haorong Lu Xiao-Ying Wang Jian Zhou Jia Fan Kui Wu Qiang Gao

Published in: Cancer discovery (2022)

This study elucidates the impact of spatial immune heterogeneity upon tumor evolution of iCCA and reveals distinct immune evasion mechanisms developed in different immune microenvironments, which can be exploited for the development of personalized immunotherapy strategies. This article is highlighted in the In This Issue feature, p. 2221.

Keyphrases

single cell
machine learning
deep learning
neural network