Impact of SARS-CoV-2 Resistance to Antiviral Monoclonal Antibody Therapy on Neutralizing Antibody Response.

Marc-Kendy PaulManish C ChoudharyAmy L HeapsRinki DeoDaniela MoisiKelley C GordonJohn W MellorsCarlee MoserPaul KlekotkaAlan LandayJudith S CurrierJoseph J EronKara W ChewDavey M SmithScott F SiegUrvi M ParikhJonathan Z Linull null

Published in: Pathogens & immunity (2024)

Emerging drug resistance after SARS-CoV-2-specific mAb therapy led to a heightened host neutralizing antibody response to the mAb-resistant variant that was associated with eventual viral clearance. This demonstrates the interplay between the antiviral treatment-directed viral evolution and subsequent host immune response in viral clearance.

Keyphrases

sars cov
monoclonal antibody
respiratory syndrome coronavirus
immune response
dengue virus
stem cells
toll like receptor
dendritic cells
combination therapy
inflammatory response
mesenchymal stem cells
coronavirus disease
smoking cessation
light emitting