Cardioprotective potential of mitochondria-targeted antioxidant, mito-TEMPO, in 5-fluorouracil-induced cardiotoxicity.

Prasad Kisan Tambe Jesil Mathew A Sanjay Bharati

Published in: Cancer chemotherapy and pharmacology (2023)

Mito-TEMPO effectively mitigated 5-FU-induced cardiotoxicity by modulating mitochondrial oxidative stress, hence may serve as a protective agent/adjuvant in 5-FU-based combinatorial chemotherapy.

Keyphrases

oxidative stress
diabetic rats
high glucose
dna damage
ischemia reperfusion injury
squamous cell carcinoma
cell death
induced apoptosis
locally advanced
risk assessment
climate change
human health
rectal cancer
heat shock
heat stress