Laherradurin Inhibits Tumor Growth in an Azoxymethane/Dextran Sulfate Sodium Colorectal Cancer Model In Vivo.
Michael Joshue Rendón-BarrónEduardo Pérez-ArteagaIzamary Delgado-WaldoJossimar Coronel-HernándezCarlos Pérez-PlasenciaFrida Rodríguez-IzquierdoRosa LinaresAlma Rosa González-EsquincaIsela Álvarez-GonzálezEduardo Madrigal-BujaidarNadia Judith Jacobo-HerreraPublished in: Cancers (2024)
Colorectal cancer (CRC) is the third most common neoplasia in the world. Its mortality rate is high due to the lack of specific and effective treatments, metastasis, and resistance to chemotherapy, among other factors. The natural products in cancer are a primary source of bioactive molecules. In this research, we evaluated the antitumor activity of an acetogenin (ACG), laherradurin (LH), isolated from the Mexican medicinal plant Annona macroprophyllata Donn.Sm. in a CRC murine model. The CRC was induced by azoxymethane-dextran sulfate sodium (AOM/DSS) in Balb/c mice and treated for 21 days with LH or cisplatin. This study shows for the first time the antitumor activity of LH in an AOM/DSS CRC model. The acetogenin diminished the number and size of tumors compared with cisplatin; the histologic studies revealed a recovery of the colon tissue, and the blood toxicity data pointed to less damage in animals treated with LH. The TUNEL assay indicated cell death by apoptosis, and the in vitro studies exhibited that LH inhibited cell migration in HCT116 cells. Our study provides strong evidence of a possible anticancer agent for CRC.
Keyphrases
- cell cycle arrest
- cell death
- cell migration
- oxidative stress
- induced apoptosis
- metabolic syndrome
- squamous cell carcinoma
- pi k akt
- radiation therapy
- risk factors
- single cell
- papillary thyroid
- skeletal muscle
- cell proliferation
- signaling pathway
- machine learning
- young adults
- case control
- insulin resistance
- artificial intelligence
- high fat diet induced
- rectal cancer
- data analysis