DNA Methylation Age Acceleration Mediates the Relationship between Systemic Inflammation and Cognitive Impairment.

Cesar Higgins Tejera Peiyao Zhu Erin B Ware Margaret T Hicken Matthew Zawistowski Lindsay C Kobayashi Dominika Seblova Jennifer J Manly Bhramar Mukherjee Katharine K Brieger

Published in: medRxiv : the preprint server for health sciences (2024)

Systemic inflammation is associated with cognitive impairment, with suggestive evidence that this relationship is partially mediated through DNA methylation age acceleration.

Keyphrases

cognitive impairment
dna methylation
genome wide
gene expression
copy number