Trimetazidine Therapy in Coronary Artery Disease: The Impact on Oxidative Stress, Inflammation, Endothelial Dysfunction, and Long-Term Prognosis.
Elena BobescuLuigi Geo MarceanuLorena DimaAndreea BalanChristian Gabriel StrempelAlexandru CovaciuPublished in: American journal of therapeutics (2021)
In patients with NSTE-ACS, TMZ added to OMT with or without interventional and/or surgical reperfusion reduced oxidative stress, endothelial dysfunction, inflammation, and major acute cardiovascular events, whereas in patients with chronic coronary syndrome, TMZ decreased oxidative stress and readmission for ACS and heart failure.
Keyphrases
- oxidative stress
- coronary artery disease
- cardiovascular events
- heart failure
- acute coronary syndrome
- dna damage
- ischemia reperfusion injury
- diabetic rats
- percutaneous coronary intervention
- induced apoptosis
- cardiovascular disease
- coronary artery bypass grafting
- liver failure
- acute myocardial infarction
- coronary artery
- stem cells
- acute heart failure
- case report
- endoplasmic reticulum stress
- aortic stenosis
- intensive care unit
- cardiac resynchronization therapy
- subarachnoid hemorrhage
- signaling pathway
- aortic valve
- acute respiratory distress syndrome
- mechanical ventilation
- heat shock protein