Admixture mapping reveals the association between Native American ancestry at 3q13.11 and reduced risk of Alzheimer's disease in Caribbean Hispanics.

Andrea R V R Horimoto Diane Xue Timothy A Thornton Elizabeth E Blue

Published in: Alzheimer's research & therapy (2021)

These results provide multiethnic evidence for a relationship between AD and multiple genes at 3q13.11 and illustrate the utility of leveraging genetic ancestry diversity via admixture mapping for new insights into AD.

Keyphrases

high resolution
genome wide
high density
genome wide association study
cognitive decline
dna methylation
transcription factor
bioinformatics analysis
mass spectrometry
genome wide identification
gene expression
mild cognitive impairment