Airway remodelling rather than cellular infiltration characterizes both type2 cytokine biomarker-high and -low severe asthma.
Latifa KhalfaouiFiona A SymonSimon CouillardBeverley HargadonRekha ChaudhuriSteve BicknellAdel Hasan MansurRahul ShrimankerTimothy Stopford Christopher HinksIan Douglas PavordStephen J FowlerVanessa BrownLorcan P McGarveyLiam G HeaneyCary D AustinPeter H HowarthJoseph R ArronDavid F ChoyPeter BraddingPublished in: Allergy (2022)
Eosinophilic tissue inflammation within proximal airways is suppressed in T2 biomarker-high and T2-low severe asthma, but inflammatory and structural cell activation is present, with sputum T2-associated cytokines highest in T2 biomarker-high patients. Airway remodelling persists and may be important for residual disease expression beyond eosinophilic exacerbations. Registered at ClincialTrials.gov: NCT02883530.