Recent advances of PIWI-interacting RNA in cardiovascular diseases.
Bo LiKai WangWei ChengBo FangYing Hui LiSu Min YangMei Hua ZhangYun Hong WangKun WangPublished in: Clinical and translational medicine (2024)
piRNA can be used as a potential therapeutic target and biomaker in CVDs. piRNA influences apoptosis, inflammation and angiogenesis by regulating epigenetic modificaions. Critical knowledge gaps remain in the unifying piRNA nomenclature and PIWI-independent function.
Keyphrases
- oxidative stress
- cardiovascular disease
- healthcare
- dna methylation
- endothelial cells
- gene expression
- endoplasmic reticulum stress
- cell death
- cell cycle arrest
- vascular endothelial growth factor
- type diabetes
- protein kinase
- human health
- coronary artery disease
- risk assessment
- signaling pathway
- climate change
- nucleic acid