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Angiopoietin-like 4 production upon treatment with hypoxia and L-mimosine in periodontal fibroblasts.

Klara JanjićAlwina SchellnerAlexander EngenhartKurt KernstockBarbara SchädlAndreas MoritzHermann Agis
Published in: Journal of periodontal research (2019)
Overall, we found that hypoxia and the hypoxia mimetic agent L-mimosine can stimulate angiopoietin-like 4 production in monolayer cultures of PDLF. This increase depends on HIF-1 activity. Future studies will reveal how the modulation of angiopoietin-like 4 in the periodontium contributes to periodontal disease and regeneration.
Keyphrases
  • endothelial cells
  • stem cells
  • current status
  • single cell
  • gene expression
  • combination therapy
  • case control
  • replacement therapy