High-mobility group box 1 fragment suppresses adverse post-infarction remodeling by recruiting PDGFRα-positive bone marrow cells.

Takasumi GotoShigeru MiyagawaKatsuto TamaiRyohei MatsuuraTakashi KidoToru KurataniKazuo ShimamuraRyoto SakaniwaAkima HaradaYoshiki Sawa

Published in: PloS one (2020)

Systemic administration of HMGB1 induced angiogenesis and reduced fibrosis by recruiting PDGFRα+ mesenchymal cells from the bone marrow, suggesting that HMGB1 administration might be a new therapeutic approach for heart failure after MI.

Keyphrases

bone marrow
heart failure
induced apoptosis
mesenchymal stem cells
high glucose
endothelial cells
cell cycle arrest
signaling pathway
diabetic rats
drug induced
stem cells
vascular endothelial growth factor
endoplasmic reticulum stress
oxidative stress
emergency department
cell death
cell proliferation
adverse drug