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Enantioselective Switch and Potential Applications in Biocatalysis.

Lucia RobustiniFrancesca Paradisi
Published in: Chimia (2023)
Enantioselectivity has always been a key feature of enzymatic synthesis. In some cases, when enzymes are not strictly enantioselective, by tuning the reaction conditions it is possible to induce an enantioselective switch. A transaminase from Halomonas elongata (ω-HeWT), while generally S-selective, could be shifted towards generating the R-enantiomer at higher concentrations of amino acceptor or ionic strength, for example. Other enzymes are reported to have a similar behavior, and here we discuss some of them and their potential applications.
Keyphrases
  • human health
  • hydrogen peroxide
  • deep learning
  • risk assessment
  • ionic liquid
  • nitric oxide
  • climate change
  • neural network
  • solid state