Multisite Detection of Tn 1549 -Mediated vanB Vancomycin Resistance in Multidrug-Resistant Enterococcus faecalis ST6 in Texas and Florida.

Shelby R SimarTruc T TranKirsten B RydellDiana PanessoGerman A ContrerasJose M MunitaRenzo O CifuentesLilian M AbboPranoti SahasrabhojaneAn Q DinhDierdre B Axell-HouseTor SavidgeSamuel A Shelburne Iii Blake M Hanson César A Arias

Published in: Antimicrobial agents and chemotherapy (2022)

In the United States, vanB -mediated resistance in enterococci is rare. We characterized three sequence type (ST) 6, vancomycin-resistant Enterococcus faecalis isolates causing bacteremia in unique patients in spatiotemporally distinct settings. Isolates were recovered between 2018 and 2020 in two cities in the United States (Houston, TX; Miami, FL). The isolates harbored the vanB operon on a chromosomally located Tn 1549 transposon, and epidemiological data suggested multiple introductions of the vanB gene cluster into ST6 E. faecalis.

Keyphrases

multidrug resistant
methicillin resistant staphylococcus aureus
genetic diversity
ejection fraction
newly diagnosed
gram negative
acinetobacter baumannii
gene expression
drug resistant
electronic health record
copy number
machine learning
amino acid