Pregnancy-specific responses to COVID-19 revealed by high-throughput proteomics of human plasma.

Nardhy Gomez-Lopez Roberto Romero María Fernanda EscobarJavier Andres CarvajalMaria Paula EchavarriaLudwig L AlbornozDaniela NasnerDerek MillerDahiana M GalloJose Galaz Marcia Arenas-HernandezGaurav BhattiBogdan DoneMaria Andrea ZambranoIsabella RamosPaula Andrea FernandezLeandro PosadaTinnakorn ChaiworapongsaEunjung JungValeria Garcia-FloresManaphat SuksaiFrancesca GotschMariachiara BoscoNandor Gabor ThanAdi Laurentiu Tarca

Published in: Communications medicine (2023)

This study represents the most comprehensive characterization of the plasma proteome of pregnant and non-pregnant COVID-19 patients. Our findings emphasize the distinct immune modulation between the non-pregnant and pregnant states, providing insight into the pathogenesis of COVID-19 as well as a potential explanation for the more severe outcomes observed in pregnant women.

Keyphrases

pregnant women
sars cov
coronavirus disease
high throughput
pregnancy outcomes
mass spectrometry
preterm birth
drug induced
metabolic syndrome
weight loss