Ovarian Reserve after Chemotherapy in Breast Cancer: A Systematic Review and Meta-Analysis.
Alessia RomitoSonia BoveIlaria RomitoDrieda ZaceIvano RaimondoSimona Maria FragomeniPierluigi Maria RinaldiDomenico PagliaraAntonella LaiFabio MarazziClaudia MarchettiIda ParisGianluca FranceschiniRiccardo MasettiGiovanni ScambiaAlessandra FabiGiorgia GarganesePublished in: Journal of personalized medicine (2021)
Although this study has some limitations, including publication bias, failure to stratify the results by some important factors and low to medium quality of the studies included, this metanalysis demonstrates that the level of AMH markedly falls after CT in BC patients, corresponding to a reduction in ovarian reserve. These findings should be routinely discussed during oncofertility counseling and used to guide fertility preservation choices in young women before starting treatment.