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Comparison of treatment effect between phase 2 and phase 3 trials in patients with inflammatory bowel disease.

Pauline WilsVipul JairathBruce E SandsFernando MagroWalter ReinischDavid T RubinSilvio DaneseCédric BaumannLaurent Peyrin Biroulet
Published in: United European gastroenterology journal (2023)
In UC, we observed a similar percentage of treatment effect for clinical and histologic outcomes between phase 2 and 3 trials but not for endoscopic outcomes. Whereas in CD, we showed a failure to reproduce similar results between phases. These results may help sponsors in the design of future drug development programs.
Keyphrases
  • patients with inflammatory bowel disease
  • public health
  • metabolic syndrome
  • type diabetes
  • adipose tissue
  • ultrasound guided
  • weight loss