Outer Retinal and Choroidal Changes in Adolescents with Long-Lasting Type 1 Diabetes.
Elisabetta PilottoEleonora CosmoTommaso TorresinMarco CoppolaJoaquin Gutierrez De Rubalcava DoblasGiulia MidenaCarlo MorettiEdoardo MidenaPublished in: Journal of clinical medicine (2023)
This study aimed to assess outer retinal layer (ORL), retinal pigment epithelium (RPE), choroid (Ch) and choriocapillaris (CC) modifications in adolescents with long-lasting (>10 years) type 1 diabetes (T1D) without (noDR) or with diabetic retinopathy (DR). ORL and RPE thickness were measured at optical coherence tomography (OCT) macular scans. Vascular parameters of Ch and CC were quantified after elaboration of macular OCT-angiography (OCTA) images. Insulin dose and auxological and metabolic parameters were correlated with OCT and OCTA findings in patients. ORL thickness was higher in DR eyes than in noDR and healthy controls (HC), and RPE thickness was higher in noDR and DR eyes than in HC, with statistical significance for some sectors in noDR versus HC. No OCTA parameters of CC and Ch differed among groups, and no significant correlation was observed with auxological and metabolic parameters. In conclusion, ORL and RPE were both increased in adolescents with long-lasting T1D. Such changes were not associated with insulin dose and glycemia control, nor to any choroid or choriocapillaris flow change clinically detectable at OCTA, and they could be potential imaging biomarkers of disease progression.
Keyphrases
- optical coherence tomography
- diabetic retinopathy
- type diabetes
- young adults
- glycemic control
- physical activity
- optic nerve
- room temperature
- editorial comment
- end stage renal disease
- insulin resistance
- newly diagnosed
- cardiovascular disease
- computed tomography
- high resolution
- ejection fraction
- chronic kidney disease
- deep learning
- patient reported outcomes
- metabolic syndrome
- magnetic resonance imaging
- human health
- photodynamic therapy
- skeletal muscle
- mass spectrometry
- machine learning
- cataract surgery