Population Pharmacokinetics of Melphalan in a Large Cohort of Autologous and Allogeneic Hematopoietic Cell Transplantation Recipients: Towards Individualized Dosing Regimens.
Gunjan L ShahJaap Jan BoelensDean CarlowAndrew LinRyan SchofieldNancy Cruz SitnerAnna AlperovichJosel RuizAnthony ProliParastoo DahiRoni TamariSergio A GiraltMichael ScordoRick AdmiraalPublished in: Clinical pharmacokinetics (2021)
The proposed model adequately describes the population pharmacokinetics of melphalan in adult patients receiving a hematopoietic cell transplantation. This model can be used to define the therapeutic window of melphalan, and subsequently to develop individualized dosing regimens aiming for that therapeutic window in all patients.